Contramid^®

Our lead technology platform, Contramid^®, can be applied to a wide variety of drugs in solid, oral dosage form to optimize compliance, safety, bioavailability and performance.

What Is It?

Contramid is a cross-linked, high amylose starch drug delivery technology that meters the release of drugs from orally administered solid dosage forms.

How Does it Work?

In its dry state, Contramid acts as a free flowing, highly compressible powder. When in tablet form and wetted, it forms a long-lasting, uniform surface membrane that is ideally suited to controlled release of orally administered drugs under a broad range of in-body conditions.

What Are Its Advantages?

Contramid has the following advantages as a controlled-release technology:

• High drug loading capacity (important for once-daily formulations);
• Flexible release profiles to maximize efficacy and minimize side effects;
• Ability to release multiple drugs from a single tablet with different release rates;
• Safe: Contramid complies with FDA and EP regulations for modified starches and may be used in any proportion in oral pharmaceuticals. Being starch-based it is also completely biodegradable.

What Have We Done With It?

Our once-daily formulation of tramadol, now on the market in Europe, validates our Contramid technology in solid, oral dosage applications. We are currently working to exploit Contramid’s potential through a number of different presentations.